KYZATREX® is a prescription oral testosterone treatment for adult men who have low or no testosterone levels due to certain medical conditions. Two doses, twice daily with food.
KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. It is not known if KYZATREX is safe or effective in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”). KYZATREX is not meant for use by women.
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A Testosterone Pill That Works

Clinically proven in a Phase III study of 139 men.
increase in mean free testosterone levels at Day 901
of men who completed the trial achieved normal testosterone levels at Day 901*
*Not actual size, Also available in 150 mg
reduction in SHBG, to free more testosterone to work in your body†2
*In a 6-month clinical trial of 139 men with low testosterone, 88% of patients achieved normal testosterone levels at Day 90 (worst-case scenario analysis, excluding Investigator Site 104). Among patients who completed the study (n=127), 96% achieved normal testosterone levels at Day 90.
†Sex Hormone Binding Globulin (SHBG) binds to testosterone and decreases free testosterone levels. The less SHBG you have, the higher your free testosterone levels will be.
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What is KYZATREX?
Ask AI
KYZATREX is an FDA-approved oral testosterone capsule for adult men with low testosterone due to certain medical conditions. It is taken twice daily with a fat-containing meal. No injections, no gels, no prior authorization required.
Disclaimer: AI responses may contain inaccuracies and are not medical advice.

Low Testosterone Symptoms Often Go Unnoticed

A blood test is the only way to confirm low testosterone. Your doctor can order one at your next visit, or you can start online.
Normal Testosterone Levels
Mulhall JP, Trost LW, Brannigan RE et al: Evaluation and management of
testosterone deficiency: AUA guideline. J Urol 2018; 200: 423.
Low Sex Drive
Low Energy
Muscle Loss
Mood Shifts
Weight Gain
Poor Sleep
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YOU ARE NOT ALONE

20 Million Men, One Simple Fix

Low testosterone (hypogonadism) affects an estimated 20 million American men ages 20–65.4,5 Testosterone deficiency is a medical condition – not a normal part of aging – and it is treatable.
Why is hypogonadism underdiagnosed?
Ask AI
The majority of men with low testosterone (hypogonadism) remain undiagnosed because symptoms — fatigue, low libido, weight gain, mood changes — are commonly attributed to stress or aging rather than a treatable medical condition. A blood test is the only way to confirm the diagnosis.
Disclaimer: AI responses may contain inaccuracies and are not medical advice.

Three Ways to Get Started

KYZATREX is available by prescription through three paths — all without prior authorization or insurance complications.
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THE FASTEST WAY
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Not available in Rhode Island and Alabama.
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Real Men. Real Results.

KYZATREX Patient Testimonials

My life has changed for the better."

"I have recently taken my health into my own hands after my labs reflected low testosterone. I have been on KYZATREX for more than 4 months now and my testosterone levels are back to normal. My life has changed for the better. I really do attribute this jumpstart in health to KYZATREX."

Brian N. Age 56

Real Patient Taking KYZATREX

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What results have patients experienced with KYZATREX?
Ask AI
In patient-reported experiences, KYZATREX use was associated with restored testosterone levels and improved well-being under physician supervision. Individual results with KYZATREX vary.
Disclaimer: AI responses may contain inaccuracies and are not medical advice.
SEE THE DIFFERENCE

Not All TRT is Created Equal

KYZATREX is designed to fit effortlessly into your life, not disrupt it.
*Not actual size, Also available in 150 mg
No Needles
No painful injections
No Mess
No sticky gels or creams
No Transference Risk
No risk of passing testosterone
to your partner or kids
What options do I have if I don’t want injections or topical treatments?
Ask AI
KYZATREX is an FDA-approved TRT option that offers an oral alternative to injections, transdermal gels, or implantable pellets.
Disclaimer: AI responses may contain inaccuracies and are not medical advice.

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No prior auth. No insurance. Just two doses a day.
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Bypasses Your Liver, By Design

Previous generations of oral testosterone were processed through the liver, creating toxicity risks that made them unsafe for long-term use. KYZATREX uses a Self-Emulsifying Drug Delivery System (SEDDS) to route testosterone through the intestinal lymphatic system, bypassing the liver entirely. It is not a 17-alpha-alkylated androgen. It is not associated with the hepatotoxicity risks of older oral testosterone agents.
Not 17-alpha-alkylated
KYZATREX's formulation is fundamentally different from older oral testosterone agents.
No known liver toxicity risk
Not associated with the liver damage risks of previous-generation oral testosterone.
KYZATREX is not known to cause hepatic adverse effects. However, patients should report any signs of hepatic dysfunction (e.g., nausea or vomiting, jaundice, dark urine, or abdominal pain). If these occur, call your doctor right away and discontinue KYZATREX.
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Frequently Asked Questions About KYZATREX

KYZATREX is an FDA-approved oral testosterone for men who have low or no testosterone levels due to certain medical conditions. It is taken twice daily with a fat-containing meal and is available by prescription only. KYZATREX is a controlled substance (CIII) because it contains testosterone.

KYZATREX is used to treat men who have low or no testosterone due to certain medical conditions.

It is not known if KYZATREX is safe or effective in children younger than 18 years old. Improper use of KYZATREX may affect bone growth in children. KYZATREX is not meant for use by women.

Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients.

Start the conversation with your doctor.

KYZATREX is taken orally, with two doses a day alongside food. Your healthcare provider will provide specific instructions based on your treatment plan.

KYZATREX is not known to cause liver side effects. It was specififcally designed to be absorbed lymphathically. This means it bypasses your liver, helping to avoid the liver toxicity often associated with previous generations and other forms of testosterone. If you experience liver problems (e.g., nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine, or abdominal pain) while taking KYZATREX, discuss these with your doctor right away.

KYZATREX is available by prescription. Consult with a healthcare provider knowledgeable about Low T management to discuss whether KYZATREX is right for you and how to obtain it.

See RX Options

KYZATREX is an immediate-release oral testosterone undecanoate. It is absorbed through the lymphatic system, where the body then uses it to replace testosterone lost due to various medical conditions.

Diagnosing Low T involves a review of your medical history and simple lab tests (done in the morning) to measure your Total Testosterone (Total T) and Free Testosterone (Free T), as well as Sex Hormone Binding Globulin (SHBG), which affects the availability of Free T. Total T gives an overall level, while Free T shows the testosterone available for your body’s use. High SHBG can lower Free T, impacting its availability. Your doctor may suggest these tests and follow-up labs to monitor your testosterone levels over time, ensuring your treatment is accurately tailored to your needs.

Learn how to talk to your doctor about Low T.

KYZATREX is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.

Do not take KYZATREX if you have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX® may harm your unborn baby); or are allergic to KYZATREX® or any of its ingredients.

The most common side effect of KYZATREX is high blood pressure. In the Phase 3 clinical trial for KYZATREX (n=155), 4 patients (2.6%) reported high blood pressure. A total of 5 patients (3.2%) began taking new antihypertensive medications after study start. No patient increased their antihypertensive medication dose.

KYZATREX can cause serious side effects. Tell your healthcare provider if you have high blood pressure, a history of diabetes, heart problems, high red blood cell count (hematocrit), high hemoglobin laboratory value, urinary problems due to an enlarged prostate, liver or kidney problems, sleep apnea, which can increase risk of side effects.

See additional Important Safety Information, including boxed warning, for KYZATREX below.

KYZATREX is a testosterone medication made available on a cash-pay basis, removing the complications of insurance. Your doctor will provide you with instructions on how to fill your KYZATREX prescription.

References:

  1. Bernstein JS, Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024;16:17562872241241864. doi: 10.1177/17562872241241864
  2. Data on file. Raleigh, NC: Marius Pharmaceuticals, 2020.
  3. Krakowsky Y, Grober E. Testosterone deficiency – Establishing a Biochemical Diagnosis. EJIFCC.2015 Mar; 26(2): 105–113.PMID: 27683486; PMCID:PMC4975356.
  4. Li Y, Liu M, Cui Y, et al. Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study. Front Endocrinol. 2022;13:975773. doi: 10.3389/fendo.2022.974773
  5. National Population by Characteristics: 2020–2022. Annual Estimates of the Resident Population for Selected Age Groups by Sex for the United States: April 1, 2020 to July 1, 2022 (NC-EST2022-SYAEXN). U.S. Census Bureau. https://www.census.gov/data/tables/time-series/demo/popest/2020s-national-detail.html. Accessed September 11, 2023.